Predictors of painkiller dependence among people with pain in the general population

Aims: Self-medication with painkillers is widespread and increasing, and evidence about influences on painkiller dependence is needed to inform efforts to prevent and treat problem painkiller use. Design: Online questionnaire survey. Participants: People in the general population who had pain and used painkillers in the last month (n=112). Measurements: Pain frequency and intensity, use of over-the-counter and prescription painkillers, risk of substance abuse (SOAPP scale), depression, anxiety, stress, alexithymia, pain catastrophizing, pain anxiety, pain self-efficacy, pain acceptance, mindfulness, self-compassion, and painkiller dependence (Leeds Dependence Questionnaire). Findings: In multiple regression, the independent predictors of painkiller dependence were prescription painkiller use (ß 0.21), SOAPP score (ß 0.31), and pain acceptance (ß -0.29). Prescription painkiller use mediated the influence of pain intensity. Alexithymia, anxiety and pain acceptance all moderated the influence of pain. Conclusions: The people most at risk of developing painkiller dependence are those who use prescription painkillers more frequently, who have a prior history of substance-related problems more generally, and who are less accepting of pain. Based on these findings, a preliminary model is presented with three types of influence on the development of painkiller dependence: a) pain leading to painkiller use, b) risk factors for substance-related problems irrespective of pain, and c) psychological factors related to pain. The model could guide further research among the general population and high risk groups, and acceptance-based interventions could be adapted and evaluated as methods to prevent and treat painkiller dependence.The Leonardo Da Vinci Lifelong Learning Programme funded Joana Duarte’s graduate research placement at the University of Derb

Could light harvesting complexes exhibit non-classical effects at room temperature?

Mounting experimental and theoretical evidence suggests that coherent quantum effects play a role in the efficient transfer of an excitation from a chlorosome antenna to a reaction center in the Fenna-Matthews-Olson protein complex. However, it is conceivable that a satisfying alternate interpretation of the results is possible in terms of a classical theory. To address this possibility, we consider a class of classical theories satisfying the minimal postulates of macrorealism and frame Leggett-Garg-type tests that could rule them out. Our numerical simulations indicate that even in the presence of decoherence, several tests could exhibit the required violations of the Leggett-Garg inequality. Remarkably, some violations persist even at room temperature for our decoherence model.Comment: 10 pages, 4 figures, 2 tables, submitted to the Proceedings of the Royal Society

The effect of music on visuospatial memory

Music was utilized in an attempt to enhance visuospatial memory. Twenty-eight individuals, who attended a United Methodist Church in southern West Virginia, were randomly assigned to experimental and control conditions. The experimental group was exposed to new age and classical compositions, counterbalanced for order effects. The new age and classical selections were of similar tempo and complexity. The control group received two relaxation periods, of a comparable length to the music presented to the experimental group. The 7/24 Spatial Recall Test was used to measure visuospatial memory. The measure was administered to each participant immediately after exposure to the music or the relaxation period. The results of the one-way analysis of variance (ANOVA) did not demonstrate a significant difference between the experimental and control groups (F = 3.559, ns). A within subjects E-test found no significant difference between the new age and classical compositions utilized as a treatment within the experimental condition (F = 0.076, ns). The contributing factors that may have been responsible for the findings and avenues for future research in the area are discussed

Elevated Thyroid Indices in Children and Adolescents with Obsessive-Compulsive Disorder: Effects of Clomipramine Treatment

Objective: To examine the basal thyroid function in pediatric Obsessive Compulsive Disorder (OCD) versus controls, and to explore the relation between baseline thyroid measures and response to clomipramine treatment, and the effects of treatment on thyroid hormones. Methods: Sixteen children and adolescents with DSM-III-R OCE and 13 control children and adolescents without psychiatric illness were compared on basal measures of thyroidstimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4). For the OCD subjects, samples were compared pre- and post- 4 weeks of treatment with clomipramine. Response of OCD symptoms was measured by the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS). Results: OCD subjects demonstrated subtle but significant elevations of TSH, T3, and T4 pre-treatment compared to controls. Clomipramine treatment was associated with significant decreases in TSH and T3 concentrations. Pre-treatment TSH and T4 concentrations correlated with reductions in CY-BOCS following 8 weeks of clomipramine. Conclusion: Elevated thyroid function at baseline may be a biomarker of OCD improvement, and may reflect aspects of the underlying pathophysiology of OCD.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63200/1/cap.2005.15.581.pd